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Nikotina

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An nikotina iyo an sarong natural na naprodusir na alkaloid sa pamilyang nightshade nin mga tinanom (pinakapredominante sa tabako asin Duboisia hopwoodii)[1] asin lakop na ginamit na is widely used recreationally bilang sarong stimulant asin anxiolytic. Bilang sarong pharmaceutical drug, ginamit iyan para sa smoking cessation tanganing i-relieve an withdrawal symptoms.[2][3][4][5] Nagseserbi an nikotina bilang sarong receptor agonist sa kadaklan na nicotinic acetylcholine receptors (nAChRs),[6][7][8] apwera sa duwang nicotinic receptor subunits (nAChRα9 asin nAChRα10) kun saen iyan nagseserbi bilang sarong receptor antagonist.[6]

  1. "Nicotine: Pharmacology, Toxicity and Therapeutic use". Journal of Smoking Cessation 9 (2): 53–59. December 2014. doi:10.1017/jsc.2014.27.
  2. "Drugs of abuse and blood-brain barrier endothelial dysfunction: A focus on the role of oxidative stress". Journal of Cerebral Blood Flow and Metabolism 36 (3): 539–554. March 2016. doi:10.1177/0271678X15616978. PMID 26661236.
  3. Error sa pag-cite: Imbalidong <ref> tatak; mayong teksto na ipinagtao para sa reperensiya na pinagngaranan na PubChem Nicotine
  4. "Nicotine: Clinical data". IUPHAR/BPS Guide to Pharmacology. International Union of Basic and Clinical Pharmacology. Used as an aid to smoking cessation and for the relief of nicotine withdrawal symptoms.
  5. Abou-Donia M (5 February 2015). Mammalian Toxicology. John Wiley & Sons. pp. 587–. ISBN 978-1-118-68285-2.
  6. 1 2 Error sa pag-cite: Imbalidong <ref> tatak; mayong teksto na ipinagtao para sa reperensiya na pinagngaranan na IUPHAR
  7. Error sa pag-cite: Imbalidong <ref> tatak; mayong teksto na ipinagtao para sa reperensiya na pinagngaranan na MalenkaNicotine
  8. "Nicotine effects and the endogenous opioid system". Journal of Pharmacological Sciences 125 (2): 117–124. 2014. doi:10.1254/jphs.14R03CP. PMID 24882143.